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KMID : 0358420110540080441
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Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 8 p.441 ~ p.447
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Expression of membrane type-2 and -3 matrix metalloproteinases in eutopic endometrium of women with advanced endometriosis
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Chung Hyun-Kyung
Lee Ji-Young
Jeong Kyung-A
Chung Hye-Won
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Abstract
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Objective: To investigate the expression of messenger RNA (mRNA) for membrane type-2 matrix metalloproteinases (MT2-MMPs) and MT3-MMP and compare their expression pattern in women with severe endometriosis and normal controls.
Methods: Quantitative competitive polymerase chain reaction was performed to evaluate the mRNA expression of MT2-MMP and MT3-MMP in endometrium from 36 women with severe endometriosis and 52 women without endometriosis throughout the menstrual cycle.
Results: Eutopic endometrium from women with endometriosis expressed higher levels of MT3-MMP than that from normal women in secretory phase (P < 0.05). MT2-MMP expression from eutopic endometrium showed no significant differences between patients with endometriosis and controls.
Conclusion: These results suggest that eutopic endometrium from patients with endometriosis may be more proteolytic, angiogenic and prone to growth because of greater MT3-MMP expression than endometrium from women without endometriosis. Thus, increased proteolytic and angiogenic activities may be one of the explanations of the pathogenesis of endometriosis.
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KEYWORD
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Membrane type-2 matrix metalloproteinases, Membrane type-3 matrix metalloproteinases, Endometriosis.
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